XERMELO™ reduces the production of serotonin

Serotonin is a hormone that helps the function in your gastrointestinal system. For some people with carcinoid syndrome, their tumors produce too much serotonin, which can cause diarrhea. XERMELO works to reduce the production of serotonin in the body.

After serotonin breaks down in your body, it is released as a chemical known as 5-HIAA, which is a key measure of serotonin.

Xermelo Can Reduce 5-HIAA Levels in as Little as 5 Days Xermelo Can Reduce 5-HIAA Levels in as Little as 5 Days

XERMELO™ can be used regardless of your 5-HIAA levels

Now you can do more to treat carcinoid syndrome diarrhea by adding XERMELO™.
Talk to your doctor to see if XERMELO™ may be right for you.

See how XERMELO™ can reduce bowel movements
Learn how XERMELO helps

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Important Safety Information and Indication

Important Safety Information

  • XERMELO may cause constipation which can be serious. You should stop taking XERMELO if severe constipation or severe, persistent, or worsening abdominal pain develops
  • The most common side effects of XERMELO include nausea, headache, increase in hepatic enzymes, depression, flatulence, decreased appetite, swelling of your hands and feet, and fever


XERMELO is a prescription pill, used along with somatostatin analog (SSA) therapy, for carcinoid syndrome diarrhea in adults who are not adequately controlled by SSA therapy.

For more information about XERMELO, talk to your doctor or see Full Prescribing Information.