how-xermelo-works

How XERMELO works

XERMELO controls Carcinoid Syndrome diarrhea, one of the most life-disrupting symptoms of Carcinoid Syndrome

XERMELO works with SSA therapy to reduce hormone overproduction and control Carcinoid Syndrome diarrhea.

XERMELO works on the inside of cells unlike other antidiarrheal medications XERMELO works on the inside of cells unlike other antidiarrheal medications
NEUROENDOCRINE TUMOR CELL
  • SSA injections are used to slow the release of serotonin in the body
  • XERMELO reduces the overproduction of serotonin inside neuroendocrine tumor cells, which can lead to less diarrhea

XERMELO is a targeted therapy for Carcinoid Syndrome diarrhea. It works directly inside the tumor, which is different than how antidiarrheal medications work.

XERMELO reduced serotonin levels, an important measure of disease severity

When serotonin breaks down in your body, it becomes 5-HIAA. People with Carcinoid Syndrome often have high levels of 5-HIAA. Your doctor may measure the 5-HIAA to see how much serotonin is in your body.

XERMELO reduced 5-HIAA levels by 43% XERMELO reduced 5-HIAA levels by 43%

XERMELO was shown to be effective regardless of your 5-HIAA levels

  • XERMELO can be used regardless of your 5-HIAA levels
  • People taking SSA injections alone experienced an increase in 5-HIAA levels (14%)

See how XERMELO can reduce bowel movements
Learn how XERMELO helps

5-HIAA=5-hydroxyindoleacetic acid; SSA=somatostatin analog.

Social Image

Important Safety Information and Indication

Important Safety Information and Indication

Important Safety Information

  • XERMELO may cause constipation which can be serious. You should stop taking XERMELO if severe constipation or severe, persistent, or worsening abdominal pain develops. Talk to your doctor if you have these symptoms
  • The most common side effects of XERMELO include nausea, headache, increase in hepatic enzymes, depression, flatulence, decreased appetite, swelling of your hands and feet, and fever
  • Talk to your doctor about all medicines you are taking as some may interact with XERMELO

Indication

XERMELO is a prescription pill, used along with somatostatin analog (SSA) therapy, for Carcinoid Syndrome diarrhea in adults who are not adequately controlled by SSA therapy.

For more information about XERMELO, talk to your doctor or see Full Prescribing Information.

You may report an adverse event related to Lexicon products by calling 1-844-LEX-PHAR (1-844-539-7427)  (US only). If you prefer, you may contact the US Food and Drug Administration (FDA) directly. The FDA has established a reporting service known as MedWatch where healthcare professionals and consumers can report serious problems they suspect may be associated with the drugs and medical devices they prescribe, dispense, or use. Visit MedWatch or call 1-800-FDA-1088.