Carcinoid Syndrome Diarrhea

What causes Carcinoid Syndrome diarrhea?

Diarrhea is one of the most common and life-disrupting symptoms of Carcinoid Syndrome. It affects nearly 80% of people with Carcinoid Syndrome. Even with somatostatin analog (SSA) treatment, some people continue to experience Carcinoid Syndrome diarrhea.

Carcinoid Syndrome diarrhea is caused by an overproduction of serotonin inside neuroendocrine tumor (NET) cells. Too much serotonin increases the amount of fluid in the gut. It also speeds up the function of the gut. This causes diarrhea, which can happen throughout the day. Short bowel syndrome, an overgrowth of bacteria in the gastrointestinal tract, and the use of SSA injections may also cause diarrhea.

Carcinoid Syndrome is a chronic condition and a cure may not be possible, however, the symptoms can be treated with medication.

If you're experiencing Carcinoid Syndrome diarrhea, ask your doctor if XERMELO could be right for you.

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Important Safety Information and Indication

Important Safety Information and Indication

Important Safety Information

  • XERMELO may cause constipation which can be serious. You should stop taking XERMELO if severe constipation or severe, persistent, or worsening abdominal pain develops. Talk to your doctor if you have these symptoms
  • The most common side effects of XERMELO include nausea, headache, increase in hepatic enzymes, depression, flatulence, decreased appetite, swelling of your hands and feet, and fever
  • Talk to your doctor about all medicines you are taking as some may interact with XERMELO


XERMELO is a prescription pill, used along with somatostatin analog (SSA) therapy, for Carcinoid Syndrome diarrhea in adults who are not adequately controlled by SSA therapy.

For more information about XERMELO, talk to your doctor or see Full Prescribing Information.

You may report an adverse event related to Lexicon products by calling 1-844-LEX-PHAR (1-844-539-7427)  (US only). If you prefer, you may contact the US Food and Drug Administration (FDA) directly. The FDA has established a reporting service known as MedWatch where healthcare professionals and consumers can report serious problems they suspect may be associated with the drugs and medical devices they prescribe, dispense, or use. Visit MedWatch or call 1-800-FDA-1088.