Prescribing InformationFor Patients
Indication
XERMELO is a tryptophan hydroxylase inhibitor indicated for the treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) therapy in adults inadequately controlled by SSA therapy.
XERMELO
(telotristat ethyl)
SSA
Combination for Control
Inhibit serotonin overproduction inside the tumor cell to control Carcinoid Syndrome Diarrhea.1
SSA = somatostatin analog
poster
Xermelo is the only oral therapy that controls serotonin overproduction at its source—inside the tumor cell.1,2
SSAs alone may not be enough
Why Combination Therapy
Control serotonin overproduction at its source1
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What your patients need to know
Using Xermelo

References:

1. XERMELO prescribing information. The Woodlands, TX: Lexicon Pharmaceuticals, Inc.; February 2017.2. Molina-Cerrillo J, Alonso-Gordoa T, Martínez-Sáez O, Grande E. Oncologist. 2016;21:701-707.

You may report an adverse event related to Lexicon products by calling 1-844-LEX-PHAR (1-844-539-7427) (US only). If you prefer, you may contact the US Food and Drug Administration (FDA) directly. The FDA has established a reporting service known as MedWatch where healthcare professionals and consumers can report serious problems they suspect may be associated with the drugs and medical devices they prescribe, dispense, or use. Visit MedWatch or call 1-800-FDA-1088.

Copyright © 2019 Lexicon Pharmaceuticals, Inc. All rights reserved.
December 2019 PP-XER-US-0053

Important Safety Information and Indication

Important Safety Information

For more information about XERMELO see Full Prescribing Information

  • Warnings and Precautions: XERMELO may cause constipation, which can be serious. Monitor for signs and symptoms of constipation and/or severe, persistent, or worsening abdominal pain in patients taking XERMELO. Discontinue XERMELO if severe constipation or severe, persistent, or worsening abdominal pain develops.
  • Adverse Reactions: The most common adverse reactions (≥5%) include nausea, headache, increased gammaglutamyl-transferase, depression, flatulence, decreased appetite, peripheral edema, and pyrexia.
  • Drug Interactions: If necessary, consider increasing the dose of concomitant CYP3A4 substrates, as XERMELO may decrease their systemic exposure. If combination treatment with XERMELO and short-acting octreotide is needed, administer short-acting octreotide at least 30 minutes after administering XERMELO.

Indication

  • XERMELO is a tryptophan hydroxylase inhibitor indicated for the treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) therapy in adults inadequately controlled by SSA therapy.

For more information about XERMELO see Full Prescribing Information