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How XERMELO works

XERMELO controls Carcinoid Syndrome diarrhea, one of the most life-disrupting symptoms of Carcinoid Syndrome

XERMELO works with SSA therapy to reduce hormone overproduction and control Carcinoid Syndrome diarrhea.

XERMELO works on the inside of cells unlike other antidiarrheal medications XERMELO works on the inside of cells unlike other antidiarrheal medications
NEUROENDOCRINE TUMOR CELL
  • SSA injections are used to slow the release of serotonin in the body
  • XERMELO reduces the overproduction of serotonin inside neuroendocrine tumor cells, which can lead to less diarrhea

XERMELO is a targeted therapy for Carcinoid Syndrome diarrhea. It works directly inside the tumor, which is different than how antidiarrheal medications work.

XERMELO reduced serotonin levels, an important measure of disease severity

When serotonin breaks down in your body, it becomes 5-HIAA. People with Carcinoid Syndrome often have high levels of 5-HIAA. Your doctor may measure the 5-HIAA to see how much serotonin is in your body.

XERMELO reduced 5-HIAA levels by 43% XERMELO reduced 5-HIAA levels by 43%

XERMELO was shown to be effective regardless of your 5-HIAA levels

  • XERMELO can be used regardless of your 5-HIAA levels
  • People taking SSA injections alone experienced an increase in 5-HIAA levels (14%)

See how XERMELO can reduce bowel movements
Learn how XERMELO helps

5-HIAA=5-hydroxyindoleacetic acid; SSA=somatostatin analog.

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