Prescribing InformationFor Patients

Enroll Your Patients

Looking to enroll your patient in LexCares?
Have you signed the enrollment form?
Physician office enrollment form
Patient financial assistance form

For Your Patients

Is your patient in need of information?

For You

Fully prepared for your patient’s authorization process?
Need to demonstrate medical necessity?
Has your patient been denied coverage?

See Sample Letters

Prior authorization letterSample letter of medical necessitySample appeal letter

If you have any questions about these forms, please call LexCares at 1-844-XERMELO.

Learn how you can add XERMELO + SSA to any tumor control regimen.

You may report an adverse event related to Lexicon products by calling 1-844-LEX-PHAR (1-844-539-7427) (US only). If you prefer, you may contact the US Food and Drug Administration (FDA) directly. The FDA has established a reporting service known as MedWatch where healthcare professionals and consumers can report serious problems they suspect may be associated with the drugs and medical devices they prescribe, dispense, or use. Visit MedWatch or call 1-800-FDA-1088.

Copyright © 2019 Lexicon Pharmaceuticals, Inc. All rights reserved.
December 2019 PP-XER-US-0053

Important Safety Information and Indication

Important Safety Information

For more information about XERMELO see Full Prescribing Information

  • Warnings and Precautions: XERMELO may cause constipation, which can be serious. Monitor for signs and symptoms of constipation and/or severe, persistent, or worsening abdominal pain in patients taking XERMELO. Discontinue XERMELO if severe constipation or severe, persistent, or worsening abdominal pain develops.
  • Adverse Reactions: The most common adverse reactions (≥5%) include nausea, headache, increased gammaglutamyl-transferase, depression, flatulence, decreased appetite, peripheral edema, and pyrexia.
  • Drug Interactions: If necessary, consider increasing the dose of concomitant CYP3A4 substrates, as XERMELO may decrease their systemic exposure. If combination treatment with XERMELO and short-acting octreotide is needed, administer short-acting octreotide at least 30 minutes after administering XERMELO.


  • XERMELO is a tryptophan hydroxylase inhibitor indicated for the treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) therapy in adults inadequately controlled by SSA therapy.

For more information about XERMELO see Full Prescribing Information