Prescribing InformationFor Patients
(telotristat ethyl)
Combination for Control
Inhibit serotonin overproduction inside the tumor cell to control Carcinoid Syndrome Diarrhea.1
SSA=somatostatin analog.
Xermelo is the only oral therapy that controls serotonin overproduction at its source—inside the tumor cell.1,2
SSAs alone may not be enough
Why Combination Therapy
Control serotonin overproduction at its source1
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What your patients need to know
Using Xermelo


1. XERMELO prescribing information. The Woodlands, TX: Lexicon Pharmaceuticals, Inc.; February 2017.2. Molina-Cerrillo J, Alonso-Gordoa T, Martínez-Sáez O, Grande E. Oncologist. 2016;21:701-707.

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Xermelo® is a registered trademark of TerSera Therapeutics LLC or its affiliates.
© 2020 TerSera Therapeutics LLC. All rights reserved.
XER-P-0040V2 (10/2020)

Important Safety Information and Indication

Important Safety Information

For more information about XERMELO see Full Prescribing Information

  • Warnings and Precautions: XERMELO may cause constipation, which can be serious. Monitor for signs and symptoms of constipation and/or severe, persistent, or worsening abdominal pain in patients taking XERMELO. Discontinue XERMELO if severe constipation or severe, persistent, or worsening abdominal pain develops.
  • Adverse Reactions: The most common adverse reactions (≥5%) include nausea, headache, increased gammaglutamyl-transferase, depression, flatulence, decreased appetite, peripheral edema, and pyrexia.
  • Drug Interactions: If necessary, consider increasing the dose of concomitant CYP3A4 substrates, as XERMELO may decrease their systemic exposure. If combination treatment with XERMELO and short-acting octreotide is needed, administer short-acting octreotide at least 30 minutes after administering XERMELO.


  • XERMELO is a tryptophan hydroxylase inhibitor indicated for the treatment of carcinoid syndrome diarrhea in combination with somatostatin analog (SSA) therapy in adults inadequately controlled by SSA therapy.

For more information about XERMELO see Full Prescribing Information